The fatal traffic crash on Highway 42 near Winston closed the highway in both directions.
Based on witness statements and evidence at the scene, a Toyota pickup being driven by a 22-year-old male was northbound on Brockway Road ran a stop sign at 50 mph and entered Hwy 42, where a westbound semi truck pulling a trailer hit the truck at a right angle in a "T-bone" crash, state police told a KPIC News crew on the scene.
After the impact, police say the Semi veered off the roadway into a field, where it turned onto it's side.
The 22-year-old female passenger in the Toyota died. The names of both people in the pickup are being withheld while next of kin notifications are being made.
The male drivers of both the semi and the Toyota were taken to Mercy Hospital in Roseburg, Ore.
The driver of the pickup was later taken by air ambulance to Emmanuel Hospital in Portland in critical condition. The driver of the semi, now identified as Dudley L. Lenhart, 42, of Tenmile, was treated and then transferred to Sacred Heart in Eugene with serious injuries.
None of the names of the people involved have been released as of 1:30 p.m.
Lt. Doug Ladd said state police expect the road to be closed for several hours while they investigate. Traffic is being detoured around the closure.
The crash happened around 10:30 a.m.
A second crash on Highway 42 on Monday involved a van traveling eastbound about one mile from Hoover Hill Road around 20 minutes after the fatal crash just a few miles down the road.
The driver, Adella J. Hood, 70, of Camas Valley was ejected after the van left the roadway. Police say the van didn't roll.
Police say that Hood was not using safety restraints, and the door appeared to be shut using a bungee cord.
Two unidentified passengers were treated for minor injuries, and Hood was transported to Legacy Emmanuel Hospital in Portland with what police are calling 'critical injuries.'
This story will be updated as more information becomes available.